In 2003, a parasitic fungal infection ravages the planet, turning humans into violent creatures known as the Infected. Twenty years later, hardened survivor Joel (Pedro Pascal) is hired to smuggle 14-year-old Ellie (Bella Ramsey) out of an oppressive quarantine zone. What should have been a quick job soon becomes a brutal, heartbreaking journey across a postapocalyptic United States, where no one can protect Joel and Ellie but each other.